A Case-Control Study of Leukemia in the U.S. Rubber Industry

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Abstract
A matched case-control study was conducted for 72 cases of leukemia occurring among employees of 4 rubber and tire manufacturing companies during the period from 1964-1973 to determine if certain environmental exposures were related to the risk of developing leukemia. Earlier studies conducted in 1 company had shown an association of lymphatic leukemia with a work history of possible solvent exposure and the results of the present study suggest that the association is weaker than previously described. Recently acquired detailed environmental information reported elsewhere tends to support the initial finding at this company. Further studies are required to fully resolve this issue. A new finding was the lack of the association in the other 3 companies. Lymphatic leukemia was associated with work experience in general service jobs for the 2 larger companies from which a majority (89%) of the cases derive. Intervals from exposure to death peaked at 27-38 yr. No elevated risk for myeloid leukemia was found.

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