PROSTAGLANDIN MEDIATED HISTAMINE TACHYPHYLAXIS IN SUBHUMAN PRIMATE TRACHEAL SMOOTH-MUSCLE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 247  (1) , 155-162
Abstract
The phenomenon of histamine tachyphylaxis previously observed in tracheal smooth muscle from canine species was investigated in isolated tracheal smooth muscle from subhuman primates [Cynomolgus macaques and Pigtail macaques]. Tachyphylaxis to histamine was readily demonstrated by repetitive exposure to histamine. Similar testing with acetylcholine did not indicate decreased responsiveness to this agent. The development of histamine tachyphylaxis could be prevented or reversed by inhibitors of prostaglandin [PG] synthesis (indomethacin, mefenamic acid, oxyphenbutazone). In indomethacin-treated tissue, exogenous administration of PGE2 reduced the histamine response. The histamine tachyphylaxis which is present in subhuman primate tracheal smooth muscle is apparently PG mediated.