Biomimetic synthesis of acridone alkaloids

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Abstract
Cyclisations of 2′-amino-, 2′-acetylamino-, or 2′-methylamino-2-methoxybenzophenones occur in the presence of sodium hydride in dimethyl sulphoxide to give acridone alkaloids. This cyclisation has relevance to the biosynthesis of these alkaloids. An alternative cyclisation can occur, giving 4-arylquinolines or 4-arylquinolones.