Alpha‐1‐antitrypsin (Pi)‐types in recurrent miscarriages

Abstract
Chromosome analysis was carried out in a consecutive series of 57 couples with a history of recurrent miscarriage. All 114 subjects from these couples had normal karyotypes by conventional analysis. Pi [.alpha.-1-antitrypsin] typing was performed in 30 couples. The constellation of Pi heterozygosity in both partners occurred in 2 of the couples. The expected frequencies of the observed MS-MS and MS-MZ constellations occurring by chance would be 2.1/1000 and 2.2/1000 couples, respectively.