REACTIONS TO PENICILLIN

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Abstract
Numerous reports have appeared in the literature of reactions similar to serum sickness and of other reactions to penicillin. These reactions have been variously treated with epinephrine, Benadryl hydrochloride (beta-dimethylaminoethyl benzohydryl ether hydrochloride), calcium gluconate, ephedrine and other preparations. Recently, State and Wangensteen1reported the use of procaine hydrochloride intravenously for actual serum sickness, and a similar case was cited by Appelbaum and others.2Prompted by these reports we are adding a case of successful treatment with procaine hydrochloride for a reaction similar to serum sickness resulting from penicillin therapy. REPORT OF A CASE E. B., a white woman aged 42, was admitted on June 17, 1946 with a history of pulmonary tuberculosis for the past ten years. She had previously been treated with artificial pneumothorax, which adequately controlled the disease. Reactivation of the tuberculous process caused her to seek readmission. Roentgenologic examination revealed a cavity in the

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