Self-trapping and anomalous dispersion of DNA in electrophoresis
- 8 June 1987
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 58 (23) , 2428-2431
- https://doi.org/10.1103/physrevlett.58.2428
Abstract
We present a high-field biased reptation model of gel electrophoresis. It is predicted that during their migration, DNA fragments can get trapped for long periods of time in near-zero–velocity, looplike compact conformations. As a consequence, the electrophoretic mobility of DNA is found to be a nonmonotonic function of the fragment size. We present experimental results showing this unique and unexpected consequence of anomalous dispersion due to DNA self-trapping in compact states.This publication has 8 references indexed in Scilit:
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