Induction of Mutation and Chromosome Damage by Excess Bases and Nucleosides

1 January 1985

book chapter
Published by Springer Nature

Vol. 31, 283-295
https://doi.org/10.1007/978-1-4613-2449-2_17

Abstract

The studies reported in this communication were conducted to determine if naturally occurring cell constituents could themselves cause mutation. All the bases and their corresponding nucleosides have been shown in culture to produce chromosome damage in P388 mouse lymphoma and Chinese hamster ovary cells (CHO) and adenosine has produced an increased incidence of sister chromatid exchanges in CHO cells. In addition thymidine has produced an increase in V79 cells resistant to 8-azaguanine and ouabain, although no effects were seen in six strains of Salmonella typhimurium. Such damage probably arises as a result of imbalanced DNA-precursor pools. Thus mutagenic events may arise by mechanisms unrelated to direct alterations of DNA.

Keywords

This publication has 29 references indexed in Scilit:

The effect of deoxyadenosine and cytosine arabinoside on the chromosomes of human leukocytes in vitro
Hereditas, 2009
Facilitation by pyrimidine deoxyribonucleosides and hypoxanthine of mutagenic and cytotoxic effects of monofunctional alkylating agents in Chinese hamster cells
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1979
Bromodeoxyuridine mutagenesis in mammalian cells is stimulated by thymidine and suppressed by deoxycytidine
Nature, 1978
Mutagenicity of thymidine to cultured Chinese hamster cells
Nature, 1978
Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test
Mutation Research/Environmental Mutagenesis and Related Subjects, 1975
Repair synthesis and induction of thymidine-resistant variants in mouse lymphoma cells of different radiosensitivity
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
Stimulation of mutation in phage T4 by lesions in gene 32 and by thymidine imbalance
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
Complete Mutagenesis in a Bacterial Population induced by Thymine Starvation on Solid Media
Nature, 1970
Chromosome aberrations induced by thymidine
Experimental Cell Research, 1966
Studies in Mutagenesis: Bacterial Mutation induced by Thymine Starvation
Nature, 1956