FOOT-AND-MOUTH DISEASE VIRUS INHIBITION INDUCED IN MICE BY SYNTHETIC DOUBLE-STRANDED RNA (POLYRIBOINOSINIC AND POLYRIBOCYTIDYLIC ACIDS)
- 1 September 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 64 (1) , 81-86
- https://doi.org/10.1073/pnas.64.1.81
Abstract
Synthetic 2-stranded RNA-a helical complex formed by duplexing homopolymers of polyriboinosinic and polyribocytidylic acids (poly I:C)-induced host resistance to foot-and-mouth disease virus when microgram quantities were injected into mice. There was a graded response as shown by titrations of polynucleotide complex or virus. Protection was effective for >48 hours after a single injection of polynucleotide complex. Survival and serum interferon titers were directly related.Keywords
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