The Effect of Deuterium on the Release and Uptake of Noradrenaline in Isolated Nerve Granules
- 1 May 1971
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 82 (1) , 131-134
- https://doi.org/10.1111/j.1748-1716.1971.tb04950.x
Abstract
The release of noradrenaline (NA) from isolated bovine splenic granules in phosphate buffer is decreased by 10–25 per cent by addition of 50–90 % D2O to the medium. The ac companying uptake of 14C(‐)NA is unchanged in 50–70 % D2O and slgihtly decreased in 95 % D2O. After previous partial NA depletion of the granules the net uptake of NA in the presence of ATP‐Mg2+ is lowered by D2O in concentrations above 25 % in the medium and has fallen to 63 per cent of normal with 87.5 % D2O.Keywords
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