Acute Renal Failure in Marathon Runners

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Abstract
The Comrades Marathon is a gruelling test of man''s stamina and only trained athletes participate. Of over 2,000 contestants each yr on a 90-km (56.25 mile) course, severe cardiac and renal damage rarely occurs. Cases [10] over 9 yr when renal damage did occur are reported. Three cases required hemodialysis; 1 had peritoneal dialysis; 2 patients had renal biopsies. Possible idiosyncratic factors are discussed as is the pathogenesis of acute tubular necrosis.

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