Intracranial reward after Lilly 110140 (fluoxetine HCl): Evidence for an inhibitory role for serotonin
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 51 (2) , 189-193
- https://doi.org/10.1007/bf00431739
Abstract
The 5-hydroxytryptamine (5-HT, serotonin) specific presynaptic reuptake inhibitor Lilly 110140 (fluoxetine hydrochloride) was injected systemically in rats trained to bar-press for rewarding stimulation to the caudal portion ofthe medial forebrain bundle. Rates of self stimulation were reduced in proportion to drug dosage, and these reductions were partially reversible by methysergide. These findings are consistent with previous reports suggesting an inhibitory role for 5-HT in self stimulation.This publication has 41 references indexed in Scilit:
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