Mapping AK1 ACONs, and AK3 to chromosome 9 in man employing an X/9 translocation and somatic cell hybrids
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 19 (1) , 26-37
- https://doi.org/10.1159/000130791
Abstract
The adenylate kinase1 (AK1), adenylate kinase3 (AK3), and aconitases (ACON3) genes have been assigned to chromosome 9 in man by employing an X/9 translocation segregating in man-mouse somatic cell hybrids. Segregation was controlled by taking advantage of the HAT/8-azaguanine selection-counterselection strategy directed at the X-linked HPRT locus. Assignment of AK1to chromosome 9 has suggested the assignment of the ABO blood-group locus and the nail-patella (Np) locus to 9, since both loci are linked to AK1by family studies.Keywords
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