In vitro activity of ceftazidime, cefotaxime and piperacillin against multi-resistant gram-negative bacteria tested with a modified agar dilution method

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Abstract
The minimum inhibitory concentrations of ceftazidime, cefotaxime and piperacillin were determined for 870 multi-resistant gram-negative bacterial strains by means of a modified agar dilution technique using dishes with 25 compartments. This technique facilitates the reading of the MICs, reduces the risk of inoculation errors, and eliminates interference of interaction of bacterial strains. Ceftazidime and cefotaxime inhibited 90 % of theEnterobacteriaceae strains at concentrations of 3.12 mg/l and 1.56 mg/l respectively. Ceftazidime and piperacillin inhibited 90 % of thePseudomonas aeruginosa strains at concentrations of 6.25 mg/l and 12.5 mg/l respectively. MucoidPseudomonas aeruginosa strains were more susceptible to the antibiotics tested, especially pipercillin, than non-mucoid strains.