Der zeitliche Verlauf der Milchsäurebildung bei der Muskelkontraktion.

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Abstract
The problem as to whether all the lactic acid produced by muscle is liberated only during the contraction phase or a part also during the period after contraction is reexamined. Semimembranosus muscles of Rana temporaria were stimulated through their nerves at regular intervals at rates of 150[long dash]300 times in 30 min. under aerobiosis and anaerobiosis in specially constructed Barcroft vessels. Both muscles were analyzed for lactic acid content and the O consumption of the aerobic muscle was measured during recovery. The value of the oxidative quotient (O.Q.), or, total lactic acid disappeared/lactic acid oxidized, was thus determined and ought to have a value not less than the highest number (6) found by Meyerhof. But, in the chief series of experiments (20 pairs of m.) the O.Q. was distinctly higher for the most part, varying between 3.2 and 11.8 (excepting one result of doubtful value); while in 11 out of the 20 (those for Oct. and Nov. when the material was at its best) the O.Q. varied between 7.3 and 11.8. This result together with other considerations leads to the conclusion that muscle working anaerobically liberates some of its lactic acid during the pause following a contraction and not all of it only during the contraction itself. It is estimated that the amount of lactic acid arising after the contraction may be as much as 1/2 of the total liberated.

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