CHEMOTHERAPY OF HUMAN TUMORS IN T-LYMPHOCYTE-DEFICIENT MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 61  (3) , 451-462
Abstract
Human lung, ovarian, colonic and renal carcinomas were grown in mice artificially deprived of T[thymus-derived]-lymphocytes. All grew slowly and were shown to have a human karyotype even after several transplant generations. Their responses to chemotherapy were similar to the expected clinical response with the important exception of hexamethylmelamine which caused complete regression of 2 lung carcinomas (even when weighing up to 2.5 g at the start of treatment) and a renal carcinoma, while completely inhibiting the growth of an ovarian carcinoma and another lung carcinoma. Measurement of plasma carcinoembryonic antigen levels was of value in assessing drug efficacy.

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