Estimation of Critical Dead Space in Respiratory Protective Devices

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Abstract
Effects of added external dead space on tidal volume, respiratory rate, pulmonary ventilation, alveolar pCO2, O2 consumption, and respiratory pressures in man were used to determine critical physiological functions. Pulmonary ventilation was most sensitive by objective measurement (significant changes above 100 ml. added dead space); resistance changes were most important subjectively. Ventilatory response was less adequate for maintenance of constant alveolar pCO2 during light exercise than at rest. "Critical" dead space was judged to be less than 100 ml. for changes in ventilatory rate; for constancy of alveolar pCO2, it was 600 ml. at rest, 400 ml. with light exercise. A composite graph is included of pulmonary ventilation effects obtained by several authors.

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