P2-Purinergic Receptors in Vascular Endothelial Cells: from Concept to Reality
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Journal of Receptor Research
- Vol. 8 (1-4) , 121-132
- https://doi.org/10.3109/10799898809048982
Abstract
ATP exerts at least 2 actions on arterial endothelial cells: it stimulates the release of endothelium-derived relaxing factor, a still unidentified vasodilator, and of prostacyclin, a potent inhibitor of platelet aggregation. A study of agonist specificity indicates that these responses are mediated by P2-purinergic receptors. We have now demonstrated that in these cells, the P2-receptors are coupled to a phospholipase C hydrolysing phospha-tidylinositol-bisphosphate and that this coupling involves a pertussis toxin-sensitive GTP-binding regulatory protein.Keywords
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