Staurosporine-induced Differentiation in a Human Neuroblastoma Cell Line, NB-1
- 1 July 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 49 (7) , 1959-1963
- https://doi.org/10.1080/00021369.1985.10867017
Abstract
A new differentiation screening system employing a human neuroblastoma cell line. NB-1, was used to isolate staurosporine as an inducer obtained from the culture broth of Streptomyces actuosus. Staurosporine at a concentration of 20 nm induced elongation of neurites and cell enlargement one hour after treatment of NB-1. In addition, the agent had a cytotoxic effect against NB-1 at a concentration of more than 0.21 μm.This publication has 6 references indexed in Scilit:
- Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.Proceedings of the National Academy of Sciences, 1981
- Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotionProceedings of the National Academy of Sciences, 1979
- Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.Proceedings of the National Academy of Sciences, 1978
- X-Ray crystal structure of staurosporine: a new alkaloid from a Streptomyces strainJournal of the Chemical Society, Chemical Communications, 1978
- DIFFERENTIATION OF HUMAN NEUROBLASTOMA CELLS IN VITRO — MORPHOLOGICAL CHANGES INDUCED BY DIBUTYRYL CYCLIC AMPActa Pathologica Japonica, 1977
- A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.The Journal of Antibiotics, 1977