Identification and characterization of a phospholipase C activity in resident mouse peritoneal macrophages. Inhibition of the enzyme by phenothiazines
- 1 August 1981
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 197 (2) , 523-526
- https://doi.org/10.1042/bj1970523
Abstract
Resident mouse peritoneal macrophages contain a phospholipase C of high activity that is specific for phosphatidylinositol. The activity has a neutral pH optimum, is Ca2+-dependent and has a maximum reaction velocity of 525nmol/h per mg of protein. Certain phenothiazines are potent inhibitors of this activity.This publication has 28 references indexed in Scilit:
- Effect of RNA and protein synthesis inhibitors on the release of inflammatory mediators by macrophages responding to phorbol myristate acetateBiochimica et Biophysica Acta (BBA) - General Subjects, 1980
- Regulation of arachidonic acid metabolites in macrophages.The Journal of Experimental Medicine, 1980
- Isolation of homogeneous phospholipase A2 from human plateletsBiochemical and Biophysical Research Communications, 1979
- Selective inhibitors of lecithin biosynthesis in mouse peritoneal macrophagesBiochemical Pharmacology, 1979
- Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotoninBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
- Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosolFEBS Letters, 1979
- Transfer of arachidonic acid to human platelet plasmalogen in response to thrombinBiochemical and Biophysical Research Communications, 1976
- METABOLIC AND MORPHOLOGICAL OBSERVATIONS ON THE EFFECT OF SURFACE-ACTIVE AGENTS ON LEUKOCYTESThe Journal of cell biology, 1967
- A semi-automated determination of phospholipidsClinica Chimica Acta; International Journal of Clinical Chemistry, 1966
- A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology, 1959