Genetic determination of antibody specificity
- 1 December 1978
- journal article
- research article
- Published by Springer Nature in The Science of Nature
- Vol. 65 (12) , 616-639
- https://doi.org/10.1007/bf00401905
Abstract
The best system for the study of cell differentiation is a cell which in its differentiated state differs only by one product. This is the case in the immune system. The undifferentiated, but omnipotent stem cell differentiates into a committed B cell which produces only one type of specific antibody out of a million different, genetically fixed possibilities. Gene translocation and fusion is the basis of this differentiation process.This publication has 155 references indexed in Scilit:
- Synthesis and isolation of DNA complementary to nucleotide sequences encoding the variable region of immunoglobulin κ chainBiochemistry, 1977
- Gene and information diversity in eukaryotesProgress in Biophysics and Molecular Biology, 1976
- Partial amino acid sequences of the heavy chains of human HLA histocompatibility antigensBiochemical and Biophysical Research Communications, 1976
- Structure of the human antibody molecule kol (immunoglobulin G1): An electron density map at 5 Å resolutionJournal of Molecular Biology, 1976
- The phylogeny of trypsin-related serine proteases and their zymogens. New methods for the investigation of distant evolutionary relationshipsJournal of Molecular Biology, 1975
- “Repetitive” DNA in higher organismsProgress in Biophysics and Molecular Biology, 1971
- On the isolation, characterisation, and crystallisation of a human Bence‐Jones protein of kappa typeFEBS Letters, 1970
- Die molekularen Grundlagen der AntikörperbildungThe Science of Nature, 1969
- Studies on papain produced subunits of human γG-globulins—IIImmunochemistry, 1966
- A Theory of the Structure and Process of Formation of Antibodies*Journal of the American Chemical Society, 1940