In Vitro Production of Metacyclic Forms ofTrypanosoma musculiand Their Infectivity in CBA Mice1

Publisher Website
Google Scholar
Abstract
Bloodstream forms of Trypanosoma musculi, cultured in Schneider''s drosophila medium at room temperature, multiply and differentiate through a series of developmental stages into infective metacyclic trypomastigotes in 10 days. Oral inoculation with these culture forms into CBA mice produced a parasitemia similar to that produced by intraperitoneal infection with bloodstream forms except for a three-day longer prepatent period. Attempts to induce parasitemia with bloodstream forms given orally were unsuccessful.