Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus.
Open Access
- 1 September 1983
- journal article
- case report
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 158 (3) , 994-999
- https://doi.org/10.1084/jem.158.3.994
Abstract
Lymphocytes from a patient who had an unusually long survival after therapy for a human T cell leukemia/lymphoma virus (HTLV)-associated T cell lymphoma were stimulated in vitro with an autologous tumor cell line, and the generation of cytotoxic T lymphocytes (CTL) was studied. CTL generated were directed against autologous (HTLV-associated tumor cells. These propagated CTL were OKT3+, OKT4-, and OKT8+. The cytotoxic activity required target tumor cells that were infected with HTLV and also expressed histocompatibility antigens in common with the patient, suggesting a major histocompatibility complex-restricted associative recognition of target antigens expressed on the tumor cell membrane.Keywords
This publication has 10 references indexed in Scilit:
- Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma.Proceedings of the National Academy of Sciences, 1982
- "Anomalous" THY-1(+) killer cells in allogeneic and F1-anti-parental mixed leukocyte culture. Relation to natural killer cells and allospecific cytotoxic T lymphocytesThe Journal of Experimental Medicine, 1982
- Retrovirus Lymphomagenesis: Relationship of Normal Immune Receptors to Malignant Cell ProliferationPublished by Springer Nature ,1982
- Possible Immunological Mechanisms in C-Type Viral Leukemogenesis in MicePublished by Springer Nature ,1982
- Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.The Journal of Experimental Medicine, 1981
- A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.The Journal of Immunology, 1981
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980
- MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and ResponsivenessPublished by Elsevier ,1979
- T-lymphocyte response to Friend virus-induced tumour cell lines in mice of strains congenic at H–2Nature, 1976
- EFFICACY OF CRYOPRESERVED SPLEEN CELLS IN MURINE TUMOR IMMUNOTHERAPYTransplantation, 1972