Immunogenesis from Cultured Marrow and Thymus Cells

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Abstract
Bone marrow cells and thymocytes were cultured together in a system that provided a suitable microenvironment for maturation of the various lymphoid cell types. The thymus-derived cells collaborated with marrow-derived cells to yield a biphasic antibody response that was not unlike primary and secondary in vivo responses. The kinetics of thymocyte-antigen reactivity and the maturation into functional T lymphocytes indicated rapid cell division over the first 9 days in vitro. These T cells were capable of serving as educated helper cells in induction of B cell terminal differentiation into antibody-forming cells. In addition these cells supported proliferation of NDV virus in the Bloom et al. assay which serves as a corollate of delayed hypersensitivity.

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