1ST-PASS MEASUREMENTS OF REGIONAL BLOOD-FLOW WITH EXTERNAL DETECTORS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 24  (7) , 577-581
Abstract
A powerful, simple model was developed for measuring regional blood flow using 1st-pass tracer kinetics with external detectors such as fast positron emission tomographs (PET). Its derivation is based on the hypothesis that during the 1st transit of a bolus of activity through an organ there exists a period during which the tracer has not left the region of interest, so that the venous concentration of the tracer is 0. Provided that this condition is met, measurement of blood flow can be obtained in any organ with any radiotracer since there are no requirements in the derivation of the model for diffusion or extraction characteristics of the tracer. The general model was demonstrated for a special case in the heart using i.v. bolus injections of 82Rb with regional positron detectors (.beta. probes) and validated by comparison with independently determined flow by labeled microspheres over a wide range of flow values from 0-5 times normal resting coronary blood flow.

This publication has 1 reference indexed in Scilit: