STRAIN DIFFERENCES IN THE RESPONSE OF THE MOUSE ADRENAL TO OESTROGEN

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Abstract
This study was limited by certain imposed parameters: the age of the mouse (2-3 months), the length of treatment (30 days), and the dose of a specific estrogen (2.5-3.5 mg pellet of estradiol). Estrogen treatment of 2-month-old male and female mice of 4 strains and of 3 reciprocal F1 hybrids for 30 days resulted in the following changes: failure to gain body weight in all but the C3H X C57 reciprocal crosses, no change in adrenal weight in all but the C3H and A females where adrenal atrophy occurred, considerable ceroid deposition in the adrenal cortex except the C3H, no change in spleen weight in all but th C57, C3H and their hybrids where splenic hypertrophy occurred, definite thymic atrophy in all treated mice. The presence of considerable lipid in the mouse adrenal cortex after chronic treatment with estrogen was stressed. The authors discussed the validity of certain endocrinologic generalizations pertaining to the effects of estrogen on growth, adrenocortical structure and function, and the thymicolymphatic system in relation to the studies made.

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