Meningitis Due to Iatrogenic Bcg Infection in Two Immunocompromised Children

Abstract
Vaccination with bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, has been used extensively throughout the world as immunoprophylaxis against tuberculosis. Since 1976, intravesical administration of BCG has been used to treat superficial transitional-cell carcinoma of the bladder.1 In both uses the complications of therapy have been rare, and the majority of serious side effects have occurred in immunocompromised persons.2-5