Regioselective C-2 and C-6 Substitution of (S)-Nicotine and Nicotine Derivatives
- 1 November 2005
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (24) , 5457-5460
- https://doi.org/10.1021/ol052196j
Abstract
Regioselective deprotonations of (S)-nicotine and derivatives at the C-2 and C-6 positions of the pyridine ring were performed in good to excellent yields. These methodologies allow the direct introduction of a plethora of functional groups onto the pyridine ring of nicotine.Keywords
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