Plasma Concentrations of Fibrinopeptide A and Fibrinopeptide Bß15-42 in Glomerulonephritis and the Nephrotic Syndrome

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Abstract
• Plasma fibrinopeptide A (FPA) and fibrinopeptide Bβ15-42 concentrations were determined by radioimmunoassay in 46 patients with glomerulonephritis and the nephrotic syndrome. An increase in plasma FPA and Bβ15-42 levels was noted in these patients; this increase was marked in the nephrotic patients. There was a positive correlation in these patients between plasma FPA and Bβ15-42 levels. The Bβ15-42/FPA ratio was significantly higher in nonnephrotic patients compared with controls. Intravascular coagulation with subsequent fibrinolysis to regulate fibrin formation may occur in patients. A positive correlation was found between plasma Bβ15-42 level and serum urea nitrogen or serum creatinine concentration, suggesting that plasma Bβ15-42 level is influenced not only by plasmin action, but also by renal dysfunction. (Arch Intern Med 1985;145:1033-1035)

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