Antigenic profiles of carcinoma cells of gastrointestinal tract, as detected by immunofluorescence technique.

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Abstract
Immunohistological studies were carried out on carcinoma cells of gastrointestinal system. The following results were obtained.1) Gastric mucosal glycoprotein, product of mucous cells in normal gastric mucosa and of Brunner's cells in the duodenum, was present in less or undifferentiated carcinoma cells of gastrointestinal tract but not in well-differentiated ones having the ordered glandular structures.2) Intestinal mucosa-specific mucosal glycoprotein, product of goblet cells in normal intestinal mucosa, was present only in gastrointestinal carcinomas of less orderly arranged glandular structures, similarly to gastric mucosal glycoprotein. It was also present in the intestinalized gastric glands.3) Placental alkaline phosphatase isoenzyme was present in carcinoma cells of both differentiated and undifferentiated type in gastrointestinal tract, but in neither intestinalized cells nor connective tissue components.4) Serum glycoprotein was found to attach firmly to carcinoma cells as “Symbodies”, resulting in the immunological unresponsiveness.5) Crossreacting antigen between gastric tumor and some normal proliferating cells (some lymphocytes of the spleen and bone marrow, and alveolar epithelial cells of the lung) was demonstrated on immunofluorescent tissue preparations.

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