Anaphylactic Reaction to Tetracycline in a Penicillin-Allergic Patient

Publisher Website
Google Scholar
Abstract
A SERUM SICKNESS-LIKE reaction consisting of fever, periorbital edema, generalized urticaria, and painful swollen joints developed in a 44-year-old white man. The patient has a history of asthmatic wheezing with colds and his father has bronchial asthma. The reaction was attributed to penicillin since it occurred four weeks after he had received a penicillin injection for an injury. He had had penicillin in the past without ill effect. The reaction subsided readily after systemic corticosteroid and antihistamine therapy. Skin tests with penicilloyl-polylysine 5×10—5molar and potassium penicillin G 10—2M, and serum passive transfer tests in two healthy subjects with penicillin G performed on Aug 31 were positive (Table 1). Passive hemagglutination of O-negative erythrocytes which had been treated with penicillin was performed by modification of a technique previously described.10.1 M 2-mercaptoethanol in saline was incubated with sera for two hours at room temperature to inactivate

This publication has 0 references indexed in Scilit: