Renal effects of aluminium in uraemic rats and in rats with intact kidney function

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Abstract
The effect on renal function following administration of aluminium i.p., five times weekly (0.05 or 0.5 mg kg−1 body weight) to partially nephrectomized (5/6 NX) or intact female rats was examined. The observed loss of concentrating ability, characterized by increased urine volume and an increased sodium excretion, as well as increased renal excretion of p-aminohippurate (demonstrable after low-dose treatment with nephrotoxins) can be interpreted as an initiation of kidney function injury. No distinct differences in reponse were observed between partially nephrectomized and intact animals.