Metabolism of 2,3,4′,6-tetrachlorobiphenyl: formation and tissue localization of mercapturic acid pathway metabolites in mice
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 17 (4) , 477-486
- https://doi.org/10.3109/00498258709043954
Abstract
1. 2,3,4′,6-Tetrachlorobiphenyl (tetraCB) and the corresponding 14C-labelled compound (14C-TetraCB) were synthesized. Two reference compounds, 4-methylthio- and 4-methylsulphonyl-2,3,4′,6-tetrachlorobiphenyl were also prepared and characterized. 2. TetraCB and 35S-cysteine were given to groups of female mice. Formation of methyl[35S]sulphonyl-tetraCB was indicated by the presence of extractable sulphuric acid-soluble radioactivity in lung, liver, kidney and fat of the tetraCB-treated mice. 3. As demonstrated by gel permeation chromatography followed by gas chromatography-mass spectrometry, the tissues of the tetraCB-treated mice contained mainly methylsulphonyl-tetraCB, minor amounts of TetraCB and traces of methylthio-TetraCB. 4. The major compound present in lung was 4-methylsulphonyl-tetraCB, indicating the presence of specific binding sites for this metabolite in lung tissue. According to autoradiography of mice injected with 14C-tetraCB, these binding sites were present mainly in the tracheo-bronchial mucosa.This publication has 17 references indexed in Scilit:
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