Tandem reactions on a zirconocene template

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Abstract
Co-cyclisation of alkenes with alkenes or alkynes and zirconocene gives zirconacycles which are further elaborated by the consecutive insertion of allyl, propargyl, or allenyl metal carbenoids and electrophiles. Insertion of other carbenoids give the first zirconacyclohexanes with the potential for further elaboration. The intramolecular co-cyclisation of 1 ,n-dienes and -enynes with 'Cp2Zr' (zirconocene) to give zirconacycles is a useful process for the synthesis of carbocyclic and heterocyclic systems1. It is most conveniently carried out using the 'zirconocene' equivalent zirconocene 1 -butene (the Negishi reagent2) formed in situ from dibutylzirconocene (Eq 1). Efficient use of the metal relies on productive elaboration of the carbon-zirconium bonds in the intermediate zirconacycle~~ and this paper summarises some of our contributions.

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