Flumequine in Atlantic salmon Salmo salar: disposition in fish held in sea water versus fresh water
Open Access
- 1 January 2002
- journal article
- Published by Inter-Research Science Center in Diseases of Aquatic Organisms
- Vol. 49 (1) , 39-44
- https://doi.org/10.3354/dao049039
Abstract
14C-labeled flumequine was administered as a single oral (5 mg kg(-1), 86 microCi kg(-1)) or intravenous (5 mg kg(-1), 82 microCi kg(-1)) dose to Atlantic salmon Salmo salar held in sea water or in fresh water. The absorption, tissue distribution and elimination were determined by means of liquid scintillation counting and whole-body autoradiography. The drug was rapidly absorbed and extensively distributed in all groups of fish. Radiolabeled compound was present in blood and muscle for more than 8 wk in the freshwater groups. In the seawater groups, however, no radioactivity was detected in the blood and muscle after 4 d and 2 wk, respectively. It was concluded that flumequine was eliminated at a substantially higher rate from Atlantic salmon in sea water than in fresh water.Keywords
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