Anabolic Effects in Man of Papain Digests of Bovine Growth Hormone

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Abstract
Bovine growth hormone has been digested with papain. Proteolysis of the protein for 2 hr. resulted in no loss of growth promoting activity in the hypophysectomized rat. After 3 hr. of papain digestion of bovine growth hormone, only one new major electrophoretic component appeared. Exposure to papain for 6 hr. produced no appreciable loss of growth promoting activity. When the papain digested growth hormone was administered to 2 hypopituitary patients, one diabetic and one nondiabetic, there was an anabolic effect in both without evidence of diabetogenicity in either.