Studies on human phenylalanine mono‐oxygenase. I. Restricted expression

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Abstract
Enzyme assays for phenylalanine mono‐oxygenase have been performed on a variety of non‐hepatic human cell types under varying conditions. The cell types studied were cultured fibroblasts, short‐term lymphocyte cultures, long‐term lymphoblastoid cultures, cultured amniotic fluid cells, hair roots and placental extracts. The cultured cells were assayed after growth under standard conditions and in the presence of a high concentration of substrate, a low concentration of end‐product, added hydrocortisone or dexamethasone and under combinations of these conditions. In no instance was a significant enzyme activity obtained.