r Carotene Hydroxylase Gene from the Cyanobacterium Synechocystis sp. PCC6803

Abstract
The ORF sll1468 of Synechocystis sp. PCC6803 was identified as a gene for rβ-carotene hydroxylase by functional complementation in a rβ-carotene-producing Escherichia coll. The gene product of ORF sll11468 added hydroxyl groups to the rβ-ionone rings of rβ-carotene (rβ,rβ-carotene) to form zeaxanthin (rβ,rβ-carotene-3,3′-diol). This newly identified rβ-carotene hydroxylase does not show overall amino acid sequence similarity to the known rβ-carotene hydroxylases. However, it showed significant sequence similarity to rβ-carotene ketolases of marine bacteria and a green alga.

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