HUMAN ALPHA-1-ANTICHYMOTRYPSIN ENHANCES PRIMARY ANTIBODY-RESPONSE IN THE MOUSE

  • 1 January 1982
    • journal article
    • research article
    • Vol. D133  (3) , 269-+
Abstract
The effect of human .alpha.-1-antichymotrypsin (.alpha.-1-Achy) on antibody response was studied in mice. .alpha.-1-Achy increased the number of anti-sheep erythrocyte antibody-producing cells. The increase was dependent on the dose of .alpha.-1-Achy injected (from 0.25 to 1 mg/mouse). .alpha.-1-Achy was effective if injected 2 days before or simultaneously with sheep erythrocytes. Asialylated .alpha.-1-Achy also enhanced the antibody response in the same as native .alpha.-1-Achy. When .alpha.-1-Achy was heated at 60.degree. C for 15 min, it appeared to maintain immunoenhancing activity. When treated at 70.degree. C for 15 min, an intermediate immunoenhancing activity was observed, and heating at 100.degree. C for 15 min resulted in loss of activity.

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