Invasive lobular carcinoma of the breast: mammographic findings and extent of disease at diagnosis in 184 patients.

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Abstract
Invasive lobular carcinoma of the breast is a distinct malignant neoplasm consisting of small cells that tend to infiltrate in thin strands that are often only one cell in width. The objectives of this study were to determine if these tumors are more frequently overlooked on mammograms than are other types of invasive carcinoma and to evaluate the specific mammographic and pathologic findings of this disease at the time of diagnosis.From 1983 through 1991, invasive, purely lobular carcinoma of the breast was diagnosed in 184 women who had screen-film mammography and biopsy at our institution. We examined the initial mammographic reports to determine the principal abnormal mammographic findings that supported or prompted biopsy and to distinguish abnormalities that were overlooked in breasts with false-negative mammographic findings. All mammograms were retrospectively examined for benign or suspicious microcalcification in the vicinity of the neoplasm and for breast parenchymal patterns. Surgical patholog...

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