Inhibitory Action of Human Epidermis on Melanin Formation

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Abstract
Aqueous extracts of human epidermis inhibit the formation of melanin from tyro-sine and from dihydroxyphenylalanin in vitro. This is due to the presence of sulfhydryl compounds in the epidermis. The hypothesis is advanced that in post-inflammatory pigmentation the oxidase acts on the substrate after sulfhydryl compounds have been oxidized or otherwise destroyed by inflammatory stimuli.