Microorganisms as Antineoplastic Agents in CNS Tumors

1 October 1983

journal article
case report
Published by American Medical Association (AMA) in Archives of Neurology

Vol. 40 (10) , 637-642
https://doi.org/10.1001/archneur.1983.04050090073012

Abstract

• In two patients, malignant tumors unexpectedly regressed following infections. I reviewed the extensive body of literature, both experimental and clinical, concerning the antineoplastic potential of bacteria and viruses. Substantial evidence exists to indicate that microorganisms may, by growing in or near tumors, completely or partially inhibit tumor growth, or alternatively may have no effect at all. In fact, oncolysis may occur only when a specific organism infects a specific tumor.

Keywords

This publication has 25 references indexed in Scilit:

CSF in Herpes Zoster Meningoencephalitis
Archives of Neurology, 1981
Serologic and Virus-Isolation Studies of Patients with Varicella or Herpes-Zoster Infection
New England Journal of Medicine, 1966
Implantation metastases.Chemotherapeutic prophylaxis and tumor growth in an infected milieu
Cancer, 1962
Herpes zoster encephalitis
The American Journal of Medicine, 1962
The Oncolytic Viruses
Published by S. Karger AG ,1959
EFFECT OF CONCURRENT INFECTIONS AND THEIR TOXINS ON THE COURSE OF LEUKEMIA
Acta Medica Scandinavica, 1958
Effects of Viruses on Tumors
Annual Review of Microbiology, 1954
VIRUSES WITH ONCOLYTIC PROPERTIES AND THEIR ADAPTATION TO TUMORS
Annals of the New York Academy of Sciences, 1952
CHEMOTHERAPY OF MALIGNANT NEOPLASTIC DISEASES
JAMA, 1950
CONTRIBUTION TO THE KNOWLEDGE OF SARCOMA
Annals of Surgery, 1891