METABOLISM OF THE STEROID HORMONES: METABOLISM OF DEHYDROISOANDROSTERONE1

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Abstract
The metabolism of dehydroisoandrosterone was studied in 2 individuals, a normal woman and a man with Addison’s disease. While this work was in progress, Mason and Kepler (1945, 1947) reported the results of administration of dehydroisoandrosterone to 3 patients. Our findings confirm those of these workers, that androsterone and etiocholanol-3(α)-one-17 were the major products obtained from dehydroisoandrosterone. These 2 compounds are also, the major products obtained after administration of testosterone (Dorfman et al., 1939; Callow, 1939). Following administration of dehydroisoandrosterone to the patient with Addison’s disease, etiocholanediol-3(α); 17(α) was also isolated, and has been previously reported (Miller and Dorfman, 1948); up to this time it had not been found to occur in human urine. experimental Melting points were determined with the Fisher-Johns apparatus and are uncorrected. 17-Ketosteroids were determined by the Holtorff-Koch (1940) method. Patient 1 (E.H.) A normal woman received 1800 mg. dehydrosisoandrosterone acetate* (equivalent to 1570 mg. dehydroisoandrosterone), injected intramuscularly in doses of 150 mg. in 3 cc.