Carcinoma of Penis: Improved Survival by Early Regional Lymphadenectomy Based on Histological Grade and Depth of Invasion of Primary Lesion

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Abstract
This study was performed to validate a new staging system and support the concept of early regional lymphadenectomy based on this system. A total of 76 cases from 4 teaching hospitals was reviewed. Of 24 patients with well or moderately differentiated noninvasive primary tumors 1 had regional metastases compared to 43 of 52 patients with poorly differentiated or invasive tumors. By classifying disease according to the depth of invasion and degree of differentiation of the primary lesions a high degree of accuracy could be obtained in predicting the likelihood of positive groin nodes. Removing groin nodes that are microscopically positive improves the survival rate over that of delayed lymphadenectomy.