Iodopyracet (Diodrast) transport by the rabbit eye

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Abstract
Iodopyracet is accumulated by the rabbit ciliary body in vitro and transported out of the living rabbit eye. Both processes resemble the analogous accumulation and active transport by the renal tubules and demonstrate similar competitive and metabolic inhibition. With increasing amounts of iodopyracet in the eye, saturation of the secretory system is demonstrated with a secretory maximum of approximately 1.2 x 10–8 moles/min.