Erythrocyte Life-Span and Sites of Destruction in Thalassemia Major

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Abstract
Clinical status, transfusion requirements, certain laboratory findings, and the survival and sites of destruction of autologous and donor erythrocytes have been evaluated and compared in 14 subjects with thalassemia major. Although varying requirements for transfusion were recognized both before and after splenectomy in different patients of this series, the need for blood transfusion was not closely correlated with hereditary aspects, erythrocyte morphology, reticulocyte levels, or the survival and sites of destruction of either autologous or donor erythrocytes. In subjects with thalassemia major, no single parameter alone may be relied upon to determine management.