Acute P. falciparum malaria induces a loss of CD28− T IFN‐γ producing cells
- 1 November 2002
- journal article
- Published by Wiley in Parasite Immunology
- Vol. 24 (11-12) , 545-548
- https://doi.org/10.1046/j.1365-3024.2002.00599.x
Abstract
SUMMARY: P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN‐γ and IL‐4 by CD28−and CD28+T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN‐γ producing CD28−T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.Keywords
This publication has 26 references indexed in Scilit:
- Identification of IFN-γ-Producing CD4+ T Cells Following PMA StimulationJournal of Interferon & Cytokine Research, 2001
- Expansion of cytotoxic CD8+ CD28− T cells in healthy ageing people, including centenariansImmunology, 1996
- Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesisAIDS, 1996
- Acute Plasmodium falciparum infection is associated with increased percentages of apoptotic cellsImmunology Letters, 1995
- Fas(CD95)/FasL interactions required for programmed cell death after T-cell activationNature, 1995
- Elevated Serum Levels of IL-10 and IFN-γ in Patients with Acute Plasmodium falciparum MalariaClinical Immunology and Immunopathology, 1995
- Fas transduces activation signals in normal human T lymphocytes.The Journal of Experimental Medicine, 1993
- Transient depletion of T cells with high LFA‐1 expression from peripheral circulation during acute Plasmodium falciparum malariaEuropean Journal of Immunology, 1991
- Tumor Necrosis Factor and Disease Severity in Children with Falciparum MalariaNew England Journal of Medicine, 1989
- The Interferon Compartment of the Immune Response in Human Malaria: II. Presence of Serum-Interferon Gamma Following the Acute AttackJournal of Interferon Research, 1985