Statistical genetic analysis of plasma levels of vitamin D: familial study
Open Access
- 1 September 1999
- journal article
- research article
- Published by Wiley in Annals of Human Genetics
- Vol. 63 (5) , 429-439
- https://doi.org/10.1046/j.1469-1809.1999.6350429.x
Abstract
The present study attempted to evaluate the relative importance of familial/genetic factors in interindividual variation of plasma concentrations of vitamin D (calcidiol). Ninety‐five nuclear pedigrees (187 males and 168 females, aged 18–91 and 18–86 years old respectively), from the Chuvasha Autonomy, Russia, were assessed for calcidiol and sex hormones. Age‐adjusted 25‐hydroxy‐vitamin D (25OHD) measures showed very high pair‐wise correlations between all members of families, which suggest that there may be a genetic factor transmitted within the families. To test this assumption, complex segregation analysis of non‐adjusted 25OHD data was undertaken, in which genotype‐sex specific dependence of the trait on age was incorporated. The analysis showed that some 44% of the 25OHD variance was attributable to all genetic and non‐genetic factors incorporated into the model. About 22% of the variation was accounted for by a putative major gene effect.Keywords
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