Effect of Derivatives and Inhibitors of Histamine Metabolism on Gastric Secretion

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Abstract
Since the derivatives of histamine metabolism are quite well known, those which have been synthesized were tested for gastric secretory activity in Heidenhain pouch dogs. All were inactive in a single total dose of 20 mg or 1.7 mg/kg. N-acetylhistamine is 1000 times less active than histamine. 1-Methyl-4-(aminoethyl) imidazole, the first derivative produced by the methylation of histamine in the liver, was inactive. Imidazole-4-acetaldehyde, the first derivative of the oxidative deamination of histamine has not been synthesized, but the next derivative, imidazole-4-acetic acid, was inactive. Among the five histamine diamine oxidase inhibitors studied in relation to gastric secretion to date, aminoguanidine is the most ideal. It has the additional advantage of not inhibiting histidine decarboxylase.

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