EFFECT OF AMPHENONE UPON STEROIDOGENESIS IN THE ADRENAL CORTEX OF THE GOLDEN HAMSTER1,2

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Abstract
In the golden hamster, amphenone does not produce the marked adrenomegaly or increase in adrenal cholesterol content seen in other species. In the hamster, too, there is no effect of amphenone on corticoidogenesis as measured by urinary steroid excretion. Administration of amphenone to the hamster results in the excretion of a metabolite that interferes with the Zimmermann test for 17-ketosteroids. It is postulated that the hamster, and perhaps other species with lipid-poor adrenals, may not utilize cholesterol as an adrenal steroid precursor, but may condense small metabolic units directly to a C21 steroid.