Interaction of a synthetic peptide of the interferon α‐2 C‐terminal part with human blood leukocytes
- 16 December 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 295 (1-3) , 70-72
- https://doi.org/10.1016/0014-5793(91)81387-n
Abstract
A biologically active synthetic peptide, 2438, representing the 124–138 amino acid sequence of the human interferon α‐2 (IFN α‐2) molecule, which is known to possess IFN‐like antiproliferative activity, specifically binds to human blood leukocytes. Scatchard plots reveal two different K fd values, for the ‘low’ and ‘high’ affinity binding. The interaction of the 125I‐labelled peptide 2438 with the cells is not impaired by human IFN α‐2 or cholera toxin.Keywords
This publication has 11 references indexed in Scilit:
- The octapeptide corresponding to the region of the highest homology between α‐interferon and thymosin‐α1 effectively competes with both cytokines for common high‐affinity receptors on murine thymocytesFEBS Letters, 1991
- The cytokine networkImmunology Today, 1989
- The Role of Three Domains in the Biological Activity of Human Interferon-αJournal of Interferon Research, 1989
- Specific residues within an amino-terminal domain of 35 residues of interferon alpha are responsible for recognition of the human interferon alpha cell receptor and for triggering biological effects.Journal of Biological Chemistry, 1987
- Analysis of the steady state binding, internalization, and degradation of human interferon-alpha2.Journal of Biological Chemistry, 1986
- [44] Procedures for studying binding of interferon to human cells in suspension culturesPublished by Elsevier ,1986
- Epstein-Barr virus susceptibility of normal human B lymphocyte populations.The Journal of Experimental Medicine, 1984
- Down-regulation of the interferon receptor.Journal of Biological Chemistry, 1982
- Specific molecular activities of recombinant and hybrid leukocyte interferons.Journal of Biological Chemistry, 1982
- Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3α,6α-diphenyl glycoluril (Iodogen)Analytical Biochemistry, 1981